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Article

c-Myc suppression of DNA double-strand break repair.

Neoplasia (New York, N.Y.) - 1 Dec 2012

Li Zhaozhong, Owonikoko Taofeek K, Sun Shi-Yong, Ramalingam Suresh S, Doetsch Paul W, Xiao Zhi-Qiang, Khuri Fadlo R, Curran Walter J, Deng Xingming

Abstract excerpt

c-Myc is a transcriptional factor that functions as a central regulator of cell growth, proliferation, and apoptosis. Overexpression of c-Myc also enhances DNA double-strand breaks (DSBs), genetic instability, and tumorigenesis. However, the mechanism(s) involved remains elusive. Here, we discovered that γ-ray ionizing radiation-induced DSBs promote c-Myc to form foci and to co-localize with γ-H2AX. Conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23308051
DOI: 10.1593/neo.121258
PMCID: PMC3540944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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