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Induced pluripotent stem cells as a model for diabetes investigation

26 Feb 2015

Abstract excerpt

Mouse and human induced pluripotent stem cells (iPSCs) may represent a novel approach for modeling diabetes. Taking this into consideration, the aim of this study was to generate and evaluate differentiation potential of iPSCs from lep(db/db) (db/db) mice, the model of diabetes type 2 as well as from patients with Maturity Onset Diabetes of the Young 3 (HNF1A MODY). Murine iPSC colonies from both wild type and...

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PMID: 25716801
DOI: 10.1038/srep08597

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