Article
The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study.
Lipids in health and disease - 11 Jan 2013
Inamori Tomoko, Goda Toshinao, Kasezawa Nobuhiko, Yamakawa-Kobayashi Kimiko
Abstract excerpt
BACKGROUND: Dyslipidemia due to high total cholesterol, LDL-cholesterol, triglycerides, or low HDL-cholesterol is an important risk factor for coronary heart disease (CHD). Both SIRT1 and PUFAs can influence the expression of genes for nuclear receptors and transcription factors related to lipid metabolism such as LXRα, LXRβ, PPARα, SREBP-1c. METHODS: A total of 707 Japanese males and 723 females were randomly...
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