Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments.

Molecular biology of the cell - 1 Mar 2013

Kakoi Shogo, Yorimitsu Tomohiro, Sato Ken

Abstract excerpt

Proteins that fail to fold in the endoplasmic reticulum (ER) are subjected to ER-associated degradation (ERAD). Certain transmembrane ERAD substrates are segregated into specialized ER subdomains, termed ER-associated compartments (ERACs), before targeting to ubiquitin-proteasome degradation. The traffic-independent function of several proteins involved in COPII-mediated ER-to-Golgi transport have been implicated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COP-Coated Vesicles
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Golgi Apparatus

Share to HSP40 Heat-Shock Proteins

Share to Proteasome Endopeptidase Complex

Share to Proteolysis

Share to Ubiquitin

Source

Open in PubMed Open full text

Identifiers

PMID: 23303252
DOI: 10.1091/mbc.E12-08-0639
PMCID: PMC3583666

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COPII machinery cooperates with ER-localized Hsp40 to sequester misfolded membrane proteins into ER-associated compartments.PMID 23303252Read ↗

Consequences of mutations in the genes of the ER export machinery COPII in vertebrates.Semantic proximity Read ↗

A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum.Semantic proximity Read ↗

Evidence for the intimate relationship between vesicle budding from the ER and the unfolded protein response.Semantic proximity Read ↗

Assembly, organization, and function of the COPII coatSemantic proximity Read ↗

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.Semantic proximity Read ↗

Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.Semantic proximity Read ↗

ER-golgi traffic is a prerequisite for efficient ER degradation.Semantic proximity Read ↗

Concentrative sorting of secretory cargo proteins into COPII-coated vesicles.Semantic proximity Read ↗

COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants.Semantic proximity Read ↗

ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains.Semantic proximity Read ↗

The sorting determinant guiding Hsp150 to the COPI-independent transport pathway in yeast.Semantic proximity Read ↗

A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.