Article
Clinical evaluation of an in-house human immunodeficiency virus (HIV) genotyping assay for the detection of drug resistance mutations in HIV-1 infected patients in Singapore.
Annals of the Academy of Medicine, Singapore - 1 Dec 2012
Chew Kuan Kiat, Ng Kah Ying, Khong Wei Xin, Kaur Palvinder, Yap Joe Kwan, Chua Arlene, Tan Mei Ting, Koh Yin Ling, Thoon Koh Cheng, Leo Yee Sin, Ng Oon Tek
Abstract excerpt
INTRODUCTION: Human immunodeficiency virus type 1 (HIV-1) genotyping resistance test (GRT) is essential for monitoring HIV-1 drug resistance mutations (DRMs). High cost and HIV-1 genetic variability are challenges to assay availability in Singapore. An in-house Sanger sequencing-based GRT method was developed at the Communicable Disease Centre (CDC), Singapore's HIV national treatment reference centre for both...
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