Article
Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture.
Tissue engineering - 1 Jun 2006
Mehlhorn A T, Schmal H, Kaiser S, Lepski G, Finkenzeller G, Stark G B, Südkamp N P
Abstract excerpt
This article addresses the stability of chondrogenic phenotype and the transdifferentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) at distinct stages of differentiation. Differentiated MSCs were expected to maintain cartilage-like gene expression pattern in the absence of any chondrogenic growth factor or in the presence of osteogenic signals. MSCs encapsulated in alginate beads were...
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