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Article

Correlated mutations and residue contacts in proteins.

Proteins - 1 Apr 1994

Göbel U, Sander C, Schneider R, Valencia A

Abstract excerpt

The maintenance of protein function and structure constrains the evolution of amino acid sequences. This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical contact in three dimensions. Here we present a simple and general method to analyze correlations in mutational behavior between different positions in a multiple sequence alignment. We...

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PMID: 8208723
DOI: 10.1002/prot.340180402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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