Article
Correlated mutations and residue contacts in proteins.
Proteins - 1 Apr 1994
Göbel U, Sander C, Schneider R, Valencia A
Abstract excerpt
The maintenance of protein function and structure constrains the evolution of amino acid sequences. This fact can be exploited to interpret correlated mutations observed in a sequence family as an indication of probable physical contact in three dimensions. Here we present a simple and general me...
Topics
- Amino Acid Sequence
- Biological Evolution
- Crystallography, X-Ray
- Mathematical Computing
- Models, Genetic
- Models, Molecular
- Models, Theoretical
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- Proteins
- Ribonuclease, Pancreatic
- Sequence Alignment
- Structure-Activity Relationship
- Trypsin Inhibitors