Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.

Circulation. Cardiovascular genetics - 1 Feb 2016

Krzywanski David M, Moellering Douglas R, Westbrook David G, Dunham-Snary Kimberly J, Brown Jamelle, Bray Alexander W, Feeley Kyle P, Sammy Melissa J, Smith Matthew R, Schurr Theodore G, Vita Joseph A, Ambalavanan Namasivayam, Calhoun David, Dell'Italia Louis, Ballinger Scott W

Abstract excerpt

BACKGROUND: We hypothesized that endothelial cells having distinct mitochondrial genetic backgrounds would show variation in mitochondrial function and oxidative stress markers concordant with known differential cardiovascular disease susceptibilities. To test this hypothesis, mitochondrial bioenergetics were determined in endothelial cells from healthy individuals with African versus European maternal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black People
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Energy Metabolism

Share to Haplotypes

Share to Human Umbilical Vein Endothelial Cells

Share to Oxidative Stress

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26787433
DOI: 10.1161/CIRCGENETICS.115.001308
PMCID: PMC4758889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.PMID 26787433Read ↗

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.Semantic proximity Read ↗

Functional Differences between Mitochondrial Haplogroup T and Haplogroup H in HEK293 Cybrid CellsSemantic proximity Read ↗

Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial-nuclear interactions.Semantic proximity Read ↗

Novel Strategies in the Early Detection and Treatment of Endothelial Cell-Specific Mitochondrial Dysfunction in Coronary Artery DiseaseSemantic proximity Read ↗

Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T.Semantic proximity Read ↗

Mitochondrial Haplogroups and Risk of Pulmonary Arterial HypertensionSemantic proximity Read ↗

Differential Epigenetic Status and Responses to Stressors between Retinal Cybrids Cells with African versus European Mitochondrial DNA: Insights into Disease Susceptibilities.Semantic proximity Read ↗

Mitochondrial dysfunction in chronic ischemia and peripheral vascular diseaseSemantic proximity Read ↗

Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy.Semantic proximity Read ↗

A link between mitochondrial DNA haplogroup and ischemia.Semantic proximity Read ↗

Sex-specific metabolic and functional differences in human umbilical vein endothelial cells from twin pairs.Semantic proximity Read ↗

Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.