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Article

Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes.

The Journal of biological chemistry - 22 Dec 2017

Bart Aaron G, Scott Emily E

Abstract excerpt

The small heme-containing protein cytochrome b5 can facilitate, inhibit, or have no effect on cytochrome P450 catalysis, often in a P450-dependent and substrate-dependent manner that is not well understood. Herein, solution NMR was used to identify b5 residues interacting with different human drug-metabolizing P450 enzymes. NMR results revealed that P450 enzymes bound to either b5 α4-5 (CYP2A6 and CYP2E1) or this...

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Identifiers

PMID: 29079577
DOI: 10.1074/jbc.RA117.000220
PMCID: PMC5743060

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