Article
Early-onset, coexisting autoimmunity and decreased HLA-mediated susceptibility are the characteristics of diabetes in Down syndrome.
Diabetes care - 1 May 2013
Aitken Rachel J, Mehers Kay L, Williams Alistair J, Brown Jamie, Bingley Polly J, Holl Reinhard W, Rohrer Tilman R, Schober Edith, Abdul-Rasoul Majedah M, Shield Julian P H, Gillespie Kathleen M
Abstract excerpt
OBJECTIVE: Down syndrome (DS) is associated with an increased risk of diabetes, particularly in young children. HLA-mediated risk is however decreased in children with DS and diabetes (DSD). We hypothesized that early-onset diabetes in children with DS is etiologically different from autoimmune diabetes. RESEARCH DESIGN AND METHODS: Clinical and immunogenetic markers of autoimmune diabetes were studied in 136...
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