Article
Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.
Diabetes - 1 Apr 2013
Gao He, Fall Tove, van Dam Rob M, Flyvbjerg Allan, Zethelius Björn, Ingelsson Erik, Hägg Sara
Abstract excerpt
The adipocyte-secreted protein adiponectin is associated with insulin sensitivity in observational studies. We aimed to evaluate whether this relationship is causal using a Mendelian randomization approach. In a sample of Swedish men aged 71 years (n = 942) from the Uppsala Longitudinal Study of Adult Men (ULSAM), insulin sensitivity (M/I ratio) was measured by the euglycemic insulin clamp. We used three genetic...
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