Article
Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis.
Circulation. Cardiovascular genetics - 1 Dec 2017
Borges Maria Carolina, Barros Aluísio J D, Ferreira Diana L Santos, Casas Juan Pablo, Horta Bernardo Lessa, Kivimaki Mika, Kumari Meena, Menon Usha, Gaunt Tom R, Ben-Shlomo Yoav, Freitas Deise F, Oliveira Isabel O, Gentry-Maharaj Aleksandra, Fourkala Evangelia, Lawlor Debbie A, Hingorani Aroon D
Abstract excerpt
BACKGROUND: Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile associated with higher blood adiponectin concentration and investigate whether variation in adiponectin concentration...
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