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Article

Long-range effects and functional consequences of stabilizing mutations in the ankyrin repeat domain of IκBα.

Journal of molecular biology - 11 Mar 2013

Cervantes Carla F, Handley Lindsey D, Sue Shih-Che, Dyson H Jane, Komives Elizabeth A

Abstract excerpt

Protein domains containing three or more ankyrin repeats (ARs) are ubiquitous in all phyla. Sequence alignments previously identified certain conserved positions, which have been shown to stabilize AR domains and promote their folding. Consensus mutations [Y254L/T257A (YLTA) and C186P/A220P (CPAP)] stabilize the naturally occuring AR domain of human IκBα to denaturation; however, only the YLTA mutations stabilize...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23274114
DOI: 10.1016/j.jmb.2012.12.012
PMCID: PMC3744861

Genes

CPAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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