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Article

Sequential unfolding of ankyrin repeats in tumor suppressor p16.

Structure (London, England : 1993) - 1 Jan 2003

Tang Kit S, Fersht Alan R, Itzhaki Laura S

Abstract excerpt

The ANK repeat is a ubiquitous 33-residue motif that adopts a beta hairpin helix-loop-helix fold. Multiple tandem repeats stack in a linear manner to produce an elongated structure that is stabilized predominantly by short-range interactions between residues close in sequence. The tumor suppressor p16(INK4) consists of four repeats and represents the minimal ANK folding unit. We found from Phi value analysis that...

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Identifiers

PMID: 12517341
DOI: 10.1016/s0969-2126(02)00929-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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