Article
Sex differences in genetic architecture of complex phenotypes?
PloS one - 1 Jan 2012
Vink Jacqueline M, Bartels Meike, van Beijsterveldt Toos C E M, van Dongen Jenny, van Beek Jenny H D A, Distel Marijn A, de Moor Marleen H M, Smit Dirk J A, Minica Camelia C, Ligthart Lannie, Geels Lot M, Abdellaoui Abdel, Middeldorp Christel M, Hottenga Jouke Jan, Willemsen Gonneke, de Geus Eco J C, Boomsma Dorret I
Abstract excerpt
We examined sex differences in familial resemblance for a broad range of behavioral, psychiatric and health related phenotypes (122 complex traits) in children and adults. There is a renewed interest in the importance of genotype by sex interaction in, for example, genome-wide association (GWA) studies of complex phenotypes. If different genes play a role across sex, GWA studies should consider the effect of...
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