Article
Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2013
Cui Yujun, Yu Chang, Yan Yanfeng, Li Dongfang, Li Yanjun, Jombart Thibaut, Weinert Lucy A, Wang Zuyun, Guo Zhaobiao, Xu Lizhi, Zhang Yujiang, Zheng Hancheng, Qin Nan, Xiao Xiao, Wu Mingshou, Wang Xiaoyi, Zhou Dongsheng, Qi Zhizhen, Du Zongmin, Wu Honglong, Yang Xianwei, Cao Hongzhi, Wang Hu, Wang Jing, Yao Shusen, Rakin Alexander, Li Yingrui, Falush Daniel, Balloux Francois, Achtman Mark, Song Yajun, Wang Jun, Yang Ruifu
Abstract excerpt
The genetic diversity of Yersinia pestis, the etiologic agent of plague, is extremely limited because of its recent origin coupled with a slow clock rate. Here we identified 2,326 SNPs from 133 genomes of Y. pestis strains that were isolated in China and elsewhere. These SNPs define the genealogy of Y. pestis since its most recent common ancestor. All but 28 of these SNPs represented mutations that happened only...
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