Article
Microevolution and history of the plague bacillus, Yersinia pestis.
Proceedings of the National Academy of Sciences of the United States of America - 21 Dec 2004
Achtman Mark, Morelli Giovanna, Zhu Peixuan, Wirth Thierry, Diehl Ines, Kusecek Barica, Vogler Amy J, Wagner David M, Allender Christopher J, Easterday W Ryan, Chenal-Francisque Viviane, Worsham Patricia, Thomson Nicholas R, Parkhill Julian, Lindler Luther E, Carniel Elisabeth, Keim Paul
Abstract excerpt
The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The microevolution of Y. pestis was therefore investigated by three different multilocus molecular methods, targeting genomewide synonymous SNPs, variation in number of tandem repeats, and insertion of IS100 insertion elements. Eight...
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