Article
Hotspots of genetic change in Yersinia pestis.
Nature communications - 4 Jan 2025
Wu Yarong, Xin Youquan, Yang Xiaoyan, Song Kai, Zhang Qingwen, Zhao Haihong, Li Cunxiang, Jin Yong, Guo Yan, Tan Yafang, Song Yajun, Tian Huaiyu, Qi Zhizhen, Yang Ruifu, Cui Yujun
Abstract excerpt
The relative contributions of mutation rate variation, selection, and recombination in shaping genomic variation in bacterial populations remain poorly understood. Here we analyze 3318 Yersinia pestis genomes, spanning nearly a century and including 2336 newly sequenced strains, to shed light on the patterns of genetic diversity and variation distribution at the population level. We identify 45 genomic regions...
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