Article
Phylogeographic variation in recombination rates within a global clone of methicillin-resistant Staphylococcus aureus.
Genome biology - 27 Dec 2012
Castillo-Ramírez Santiago, Corander Jukka, Marttinen Pekka, Aldeljawi Mona, Hanage William P, Westh Henrik, Boye Kit, Gulay Zeynep, Bentley Stephen D, Parkhill Julian, Holden Matthew T, Feil Edward J
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) is a powerful tool for understanding both patterns of descent over time and space (phylogeography) and the molecular processes underpinning genome divergence in pathogenic bacteria. Here, we describe a synthesis between these perspectives by employing a recently developed Bayesian approach, BRATNextGen, for detecting recombination on an expanded NGS dataset of the...
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