Article
Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus.
Nature communications - 23 May 2014
Everitt Richard G, Didelot Xavier, Batty Elizabeth M, Miller Ruth R, Knox Kyle, Young Bernadette C, Bowden Rory, Auton Adam, Votintseva Antonina, Larner-Svensson Hanna, Charlesworth Jane, Golubchik Tanya, Ip Camilla L C, Godwin Heather, Fung Rowena, Peto Tim E A, Walker A Sarah, Crook Derrick W, Wilson Daniel J
Abstract excerpt
Horizontal gene transfer is an important driver of bacterial evolution, but genetic exchange in the core genome of clonal species, including the major pathogen Staphylococcus aureus, is incompletely understood. Here we reveal widespread homologous recombination in S. aureus at the species level, in contrast to its near-complete absence between closely related strains. We discover a patchwork of hotspots and...
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