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Evolutionary Dynamics of Pandemic Methicillin-Sensitive Staphylococcus aureus ST398 and Its International Spread via Routes of Human Migration.

mBio - 17 Jan 2017

Uhlemann Anne-Catrin, McAdam Paul R, Sullivan Sean B, Knox Justin R, Khiabanian Hossein, Rabadan Raul, Davies Peter R, Fitzgerald J Ross, Lowy Franklin D

Abstract excerpt

Methicillin-susceptible Staphylococcus aureus (MSSA) accounts for the majority of S. aureus infections globally, and yet surprisingly little is known about its clonal evolution. We applied comparative whole-genome sequencing (WGS) analyses to epidemiologically and geographically diverse ST398-MSSA, a pandemic lineage affecting both humans and livestock. Bayesian phylogenetic analysis predicted divergence of...

Topics

Animals
Disease Transmission, Infectious
Genetic Variation
Genotype
Global Health
Human Migration
Humans
Molecular Epidemiology
Pandemics
Phylogeography

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Staphylococcal Infections

Staphylococcus aureus

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Identifiers

PMID: 28096484
DOI: 10.1128/mBio.01375-16
PMCID: PMC5241395

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