Article
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
Genome research - 1 Apr 2013
Holden Matthew T G, Hsu Li-Yang, Kurt Kevin, Weinert Lucy A, Mather Alison E, Harris Simon R, Strommenger Birgit, Layer Franziska, Witte Wolfgang, de Lencastre Herminia, Skov Robert, Westh Henrik, Zemlicková Helena, Coombs Geoffrey, Kearns Angela M, Hill Robert L R, Edgeworth Jonathan, Gould Ian, Gant Vanya, Cooke Jonathan, Edwards Giles F, McAdam Paul R, Templeton Kate E, McCann Angela, Zhou Zhemin, Castillo-Ramírez Santiago, Feil Edward J, Hudson Lyndsey O, Enright Mark C, Balloux Francois, Aanensen David M, Spratt Brian G, Fitzgerald J Ross, Parkhill Julian, Achtman Mark, Bentley Stephen D, Nübel Ulrich
Abstract excerpt
The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones that cause outbreaks and epidemics associated with health care. The most rapidly spreading and tenacious...
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