Evolution of MRSA during hospital transmission and intercontinental spread.

doi:10.1126/science.1182395

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Article

Evolution of MRSA during hospital transmission and intercontinental spread.

Science (New York, N.Y.) - 22 Jan 2010

Harris Simon R, Feil Edward J, Holden Matthew T G, Quail Michael A, Nickerson Emma K, Chantratita Narisara, Gardete Susana, Tavares Ana, Day Nick, Lindsay Jodi A, Edgeworth Jonathan D, de Lencastre Hermínia, Parkhill Julian, Peacock Sharon J, Bentley Stephen D

Abstract excerpt

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global...

Topics

Asia
Bacterial Typing Techniques
Cross Infection
Europe
Evolution, Molecular
Genome, Bacterial
Genomics
Humans
Likelihood Functions
Methicillin-Resistant Staphylococcus aureus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Epidemiology

Molecular Sequence Data

Phylogeny

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

South America

Staphylococcal Infections

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20093474
DOI: 10.1126/science.1182395
PMCID: PMC2821690

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