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Article

Evolution of MRSA during hospital transmission and intercontinental spread.

Science (New York, N.Y.) - 22 Jan 2010

Harris Simon R, Feil Edward J, Holden Matthew T G, Quail Michael A, Nickerson Emma K, Chantratita Narisara, Gardete Susana, Tavares Ana, Day Nick, Lindsay Jodi A, Edgeworth Jonathan D, de Lencastre Hermínia, Parkhill Julian, Peacock Sharon J, Bentley Stephen D

Abstract excerpt

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global...

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Identifiers

PMID: 20093474
DOI: 10.1126/science.1182395
PMCID: PMC2821690

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