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Article

Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.

Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2011

Ruel Theodore D, Kamya Moses R, Li Pelin, Pasutti William, Charlebois Edwin D, Liegler Teri, Dorsey Grant, Rosenthal Philip J, Havlir Diane V, Wong Joseph K, Achan Jane

Abstract excerpt

BACKGROUND: Without virologic testing, HIV-infected African children starting antiretroviral (ARV) therapy are at risk for undetected virologic failure and the development of ARV resistance. We sought to determine the prevalence of early virologic failure (EVF), to characterize the evolution of ARV-resistance mutations and to predict the impact on second-line therapy. METHODS: The prevalence of EVF (HIV RNA >400...

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Anti-HIV Agents
CD4 Lymphocyte Count
Drug Resistance, Viral
HIV
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

pol Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 21099693
DOI: 10.1097/QAI.0b013e3181fbcbf7
PMCID: PMC3078046

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