Article
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Zutter M, Hockett R D, Roberts C W, McGuire E A, Bloomstone J, Morton C C, Deaven L L, Crist W M, Carroll A J, Korsmeyer S J
Abstract excerpt
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Translocation introduced chromosome segment 10q24 as proven by hybridization of a breakpoint-derived probe to flow-sorted...
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