Article
The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990
Zutter M, Hockett R D, Roberts C W, McGuire E A, Bloomstone J, Morton C C, Deaven L L, Crist W M, Carroll A J, Korsmeyer S J
Abstract excerpt
We cloned the t(10;14) recurrent translocation from CD3-negative T-cell acute lymphoblastic leukemia cells. The breakpoint at 14q11 involved an intermediate rearrangement of the delta T-cell receptor locus, suggesting that the translocation arose at the time of antigen receptor assemblage. Transl...
Topics
- Alleles
- Antigens, CD
- Base Sequence
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 14
- Cloning, Molecular
- DNA, Neoplasm
- Gene Rearrangement, T-Lymphocyte
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Macromolecular Substances
- Molecular Sequence Data
- Receptors, Antigen, T-Cell