Article
Intronic BCL-6 mutations are preferentially targeted to the translocated allele in t(3;14)(q27;q32) non-Hodgkin B-cell lymphoma.
Blood - 1 Sept 2003
Jardin Fabrice, Bastard Christian, Contentin Nathalie, Parmentier Francoise, Picquenot Jean-Michel, Tilly Herve, Stevenson Freda K, Sahota Surinder S
Abstract excerpt
Translocations and somatic mutations are common genetic alterations of the BCL-6 gene on chromosome 3q27 in B-cell lymphoma, with implications for lymphomagenesis. The 2 events may have linked origins and can influence juxtaposed loci. To evaluate this further, we compared mutations occurring within the major mutation cluster region of the translocated and untranslocated BCL-6 alleles in 7 t(3;14)(q27;14q32)...
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