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Article

Multiple sites of action of volatile anesthetics in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1990

Morgan P G, Sedensky M, Meneely P M

Abstract excerpt

The mechanism and site(s) of action of volatile anesthetics are unknown. In all organisms studied, volatile anesthetics adhere to the Meyer-Overton relationship--that is, a ln-ln plot of the oil-gas partition coefficients versus the potencies yields a straight line with a slope of -1. This relati...

Topics

Anesthetics
Animals
Caenorhabditis
Dose-Response Relationship, Drug
Enflurane
Ether
Halothane
Heterozygote
Homozygote
Isoflurane
Mutation
Phenotype

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Identifiers

PMID: 2326259
DOI: 10.1073/pnas.87.8.2965
PMCID: PMC53814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2326259-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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