Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies.

doi:10.1016/j.fct.2020.111549

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Article

Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Sept 2020

Vasconcelos Mirley Alves, Orsolin Priscila Capelari, Oliveira Victor Constante, Lima Paula Marynella Alves Pereira, Naves Maria Paula Carvalho, de Morais Cássio Resende, Nicolau-Júnior Nilson, Bonetti Ana Maria, Spanó Mário Antônio

Abstract excerpt

Vitamin D3 (VD3) deficiency increases DNA damage, while supplementation may exert a pro-oxidant activity, prevent viral infections and formation of tumors. The aim of this study was to investigate the mutagenicity and carcinogenicity of VD3 alone or in combination with doxorubicin (DXR) using the Somatic Mutation and Recombination Test and the Epithelial Tumor Test, both in Drosophila melanogaster. For better...

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Identifiers

PMID: 32640329
DOI: 10.1016/j.fct.2020.111549
PMCID: PMC7335493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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