Article
Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample.
Human immunology - 1 Mar 2013
Franco Liran, Williams Frances M K, Trofimov Svetlana, Surdulescu Gabriela, Spector Timothy D, Livshits Gregory
Abstract excerpt
OBJECTIVE: Soluble fractalkine (sFRACT) is involved in the pathogenesis of several clinical diseases. Our major objective was to determine to what extent its variation is governed by genetic factors and whether this genetic variation could be attributable to SNPs in five candidate genes: CX3CL1, CX3CR1, ADAM10, ADAM17 and AREG. METHODS: Plasma levels of sFRACT and 38 SNPs, with minor allele frequency >0.1 were...
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