Article
Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence.
Molecular & cellular proteomics : MCP - 1 Dec 2009
Lin Miao-Hsia, Hsu Tung-Li, Lin Shu-Yu, Pan Yi-Jiun, Jan Jia-Tsrong, Wang Jin-Town, Khoo Kay-Hooi, Wu Shih-Hsiung
Abstract excerpt
Encapsulated Klebsiella pneumoniae is the predominant causative agent of pyogenic liver abscess, an emerging infectious disease that often complicates metastatic meningitis or endophthalmitis. The capsular polysaccharide on K. pneumoniae surface was determined as the key to virulence. Although the regulation of capsular polysaccharide biosynthesis is largely unclear, it was found that protein-tyrosine kinases and...
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