Article
The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.
Antimicrobial agents and chemotherapy - 1 Mar 2013
LaMarre Jacqueline, Mendes Rodrigo E, Szal Teresa, Schwarz Stefan, Jones Ronald N, Mankin Alexander S
Abstract excerpt
The clinical Staphylococcus epidermidis isolate 426-3147L exhibits an unusually high resistance to linezolid that exceeds 256 μg/ml. The presence of the cfr gene, encoding the RNA methyltransferase targeting an rRNA nucleotide located in the linezolid binding site, accounts for a significant fraction of resistance. The association of cfr with a multicopy plasmid is one of the factors that contribute to its...
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