Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Environment and Stability of <i>cfr</i> in Methicillin-Resistant Staphylococcus aureus CM05

25 Oct 2011

Abstract excerpt

The Cfr methyltransferase confers resistance to many 50S ribosomal subunit-targeted antibiotics, including linezolid (LZD), via methylation of the 23S rRNA base A2503 in the peptidyl transferase center. Methicillin-resistant Staphylococcus aureus strain CM05 is the first clinical isolate documented to carry cfr. While cfr is typically plasmid borne, in CM05 it is located on the chromosome and is coexpressed with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Antimicrobial Resistance in Staphylococcus
Share to Bacterial Genetics and Biotechnology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22024827
DOI: 10.1128/aac.05420-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Environment and Stability of <i>cfr</i> in Methicillin-Resistant Staphylococcus aureus CM05PMID 22024827Read ↗

Linezolid-Resistant Staphylococcus aureus Strain 1128105, the First Known Clinical Isolate Possessing the<i>cfr</i>Multidrug Resistance GeneSemantic proximity Read ↗

Emergence and Spread of <i>cfr</i> -Mediated Multiresistance in Staphylococci: An Interdisciplinary ChallengeSemantic proximity Read ↗

The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.Semantic proximity Read ↗

Transferable Plasmid-Mediated Resistance to Linezolid Due to <i>cfr</i> in a Human Clinical Isolate of Enterococcus faecalisSemantic proximity Read ↗

First Report of cfr -Carrying Plasmids in the Pandemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type IV CloneSemantic proximity Read ↗

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis InhibitorsSemantic proximity Read ↗

Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant<i>Staphylococcus aureus</i>resistant to the synthetic antibiotic linezolidSemantic proximity Read ↗

Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteriaSemantic proximity Read ↗

Linezolid resistance in clinical isolates of Staphylococcus epidermidis from German hospitals and characterization of two cfr-carrying plasmids.Semantic proximity Read ↗

Emergence of Linezolid-Resistant <i>Staphylococcus aureus</i> after Prolonged Treatment of Cystic Fibrosis Patients in Cleveland, OhioSemantic proximity Read ↗

DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in ItalySemantic proximity Read ↗

Remodelling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in Methicillin-Resistant <i>Staphylococcus aureus</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.