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Article

Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

26 Jul 2012

Abstract excerpt

Local hyperthermia is an effective treatment modality to augment radio- and chemotherapy-based anti-cancer treatments. Although the effect of hyperthermia is pleotropic, recent experiments revealed that homologous recombination, a pathway of DNA repair, is directly inhibited by hyperthermia. The hyperthermia-induced DNA repair deficiency is enhanced by inhibitors of the cellular heat-shock response. Taken...

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PMID: 22834701
DOI: 10.3109/02656736.2012.695427

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