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Article

Genotypes and phenotypes of CYP3A in Bangladeshi population.

Clinica chimica acta; international journal of clinical chemistry - 18 Mar 2011

Al Maruf Abdullah, Ahmed Maizbha Uddin, Yasmin Hasina, Ullah Md Ashik, Azad M A K, Daly Ann K, Hasnat Abul

Abstract excerpt

BACKGROUND: To investigate whether interindividual variation in CYP3A levels can partly be explained by genetic polymorphisms, this study was designed to phenotype 200 healthy Bangladeshi subjects by measuring urinary ratio of 6β-hydroxy-cortisol/cortisol and to genotype all the subjects for the presence of CYP3A4*1B, *2, *4, *5, *6, *10 and *18 and CYP3A5*3 alleles. METHODS: For phenotyping, cortisol and...

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Identifiers

PMID: 21114969
DOI: 10.1016/j.cca.2010.11.031

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