Article
Mutations in the principal neutralization determinant of human immunodeficiency virus type 1 affect syncytium formation, virus infectivity, growth kinetics, and neutralization.
Journal of virology - 1 Apr 1992
Grimaila R J, Fuller B A, Rennert P D, Nelson M B, Hammarskjöld M L, Potts B, Murray M, Putney S D, Gray G
Abstract excerpt
The principal neutralization determinant (PND) of human immunodeficiency virus type 1 envelope glycoprotein gp120 contains a conserved GPG sequence. The effects of a 29-amino-acid deletion of most of the PND, a 3-amino-acid deletion in the GPG sequence, and 16 single-amino-acid substitutions in the GPG sequence were determined in a transient expression assay. All mutant envelope glycoproteins were expressed at...
Topics
- Amino Acid Sequence
- Base Sequence
- Blotting, Western
- CD4 Antigens
- Cell Line
- DNA, Viral
- Giant Cells
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV-1