Article
Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.
PloS one - 1 Jan 2012
Papatheodorou Irene, Ziehm Matthias, Wieser Daniela, Alic Nazif, Partridge Linda, Thornton Janet M
Abstract excerpt
A challenge of systems biology is to integrate incomplete knowledge on pathways with existing experimental data sets and relate these to measured phenotypes. Research on ageing often generates such incomplete data, creating difficulties in integrating RNA expression with information about biological processes and the phenotypes of ageing, including longevity. Here, we develop a logic-based method that employs...
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