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Article

Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine.

Journal of lipid research - 1 Mar 2013

Wong Winifred P S, Altemus Jessica B, Hester James F, Chan Ernest R, Côté Jean-François, Serre David, Sehayek Ephraim

Abstract excerpt

We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effects. Fine-mapping narrowed the locus to a critical 6.3 Mb interval. Female subcongenics, but not...

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Identifiers

PMID: 23248330
DOI: 10.1194/jlr.M034579
PMCID: PMC3617955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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