Consideration of plausible genetic architectures for schizophrenia and implications for analytic approaches in the era of next generation sequencing.

Abstract excerpt

The results of linkage and association studies imply that there are no common, dominantly active variants which have a substantial effect on the risk of schizophrenia. However, there are rare structural variants with a major effect and it is argued that results to date are not incompatible with the existence of large numbers of individually rare sequence variants with major effect, since these would not have been...

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