Article
Novel association approach for determining the genetic predisposition to schizophrenia: case-control resource and testing of a candidate gene.
American journal of medical genetics - 1 May 1993
Sobell J L, Heston L L, Sommer S S
Abstract excerpt
We have developed a two-tiered approach to elucidating the genetic predisposition to schizophrenia. The approach first involves the examination of candidate genes in a subset of schizophrenic individuals to identify DNA sequence variations of likely functional significance, i.e., that produce either structural alterations in the protein or affect the level of gene expression. Once identified, the prevalence of...
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