Article
The HLA-G low expressor genotype is associated with protection against bipolar disorder.
Human immunology - 1 May 2013
Debnath Monojit, Busson Marc, Jamain Stéphane, Etain Bruno, Hamdani Nora, Oliveira José, Boukouaci Wahid, Amokrane Kahina, Moins-Teisserenc Hélène, Lajnef Mohamed, Bengoufa Djaouida, Malafosse Alain, Bellivier Frank, Henry Chantal, Kahn Jean-Pierre, Krishnamoorthy Rajagopal, Charron Dominique, Leboyer Marion, Tamouza Ryad
Abstract excerpt
Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.