Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism.

doi:10.1016/j.atherosclerosis.2011.07.092

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Article

Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism.

Atherosclerosis - 1 Oct 2011

Garcia-Rios Antonio, Delgado-Lista Javier, Perez-Martinez Pablo, Phillips Catherine M, Ferguson Jane F, Gjelstad Ingrid M F, Williams Christine M, Karlström Brita, Kieć-Wilk Beata, Blaak Ellen E, Lairon Denis, Planells Richard, Malczewska-Malec Małgorzata, Defoort Catherine, Riserus Ulf, Saris Wim H M, Lovegrove Julie A, Drevon Christian A, Roche Helen M, Lopez-Miranda Jose

Abstract excerpt

OBJECTIVE: To investigate whether seven common single nucleotide polymorphisms (SNPs) at the lipoprotein lipase (LPL) locus interact with total plasma fatty acids to modulate plasma lipid metabolism in metabolic syndrome (MetS) patients. METHODS: Plasma fatty acid composition, plasma lipid concentrations and LPL SNPs were determined in 452 subjects with the MetS in the European LIPGENE human study and were...

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PMID: 21840003
DOI: 10.1016/j.atherosclerosis.2011.07.092

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