Article
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site.
PloS one - 20 Apr 2011
Richardson Kris, Louie-Gao Qiong, Arnett Donna K, Parnell Laurence D, Lai Chao-Qiang, Davalos Alberto, Fox Caroline S, Demissie Serkalem, Cupples L Adrienne, Fernandez-Hernando Carlos, Ordovas Jose M
Abstract excerpt
PLIN4 is a member of the PAT family of lipid storage droplet (LSD) proteins. Associations between seven single nucleotide polymorphisms (SNPs) at human PLIN4 with obesity related phenotypes were investigated using meta-analysis followed by a determination if these phenotypes are modulated by interactions between PLIN4 SNPs and dietary PUFA. Samples consisted of subjects from two populations of European ancestry....
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