Article
Resequencing the untranslated regions of the lipoprotein lipase (LPL) gene reveals that variants in microRNA target sequences are associated with triglyceride levels.
Journal of clinical lipidology - 1 Jan 2000
Evans David, Beil Frank Ulrich, Aberle Jens
Abstract excerpt
BACKGROUND: Rare variants in the protein coding regions of the lipoprotein lipase (LPL) gene have been shown to be important in the development of hypertriglyceridemia. OBJECTIVES: The aim of this study was to determine whether rare variants in the 3' and 5' untranslated regions (UTRs) of the LPL gene are also associated with severe hypertriglyceridemia. METHODS: The DNA sequences of the 3' and 5' UTRs of the LPL...
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