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Article

The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking region.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2006

Trujillo Miguel A, Sakagashira Michiko, Eberhardt Norman L

Abstract excerpt

Alu family sequences are middle repetitive short interspersed elements (SINEs) dispersed throughout vertebrate genomes that can modulate gene transcription. The human (h) GH locus contains 44 complete and four partial Alu elements. An Sx Alu repeat lies in close proximity to the hGH-1 and hGH-2 genes in the 3'-flanking region. Deletion of the Sx Alu repeat in reporter constructs containing hGH-1 3'-flanking...

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Identifiers

PMID: 16762973
DOI: 10.1210/me.2006-0147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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