The Vitamin D-Responsive Element in the Rat Bone Gla Protein Gene Is an Imperfect Direct Repeat That Cooperates with Other Cis-Elements in 1,25-Dihydroxyvitamin D₃- Mediated Transcriptional Activation

Abstract excerpt

The gene for rat bone gla protein (BGP) was isolated and 1250 basepairs (bp), including 1100 bp of 5' flanking DNA, were placed up-stream of the human GH reporter gene. After transient transfection into the osteoblast-like rat osteosarcoma cell line ROS 17/2.8, the BGP promoter demonstrated a low level of basal activity that was increased approximately 10-fold by the addition of 10(-8) M 1,25-dihydroxyvitamin D3...

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