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Article

Daxx regulates mitotic progression and prostate cancer predisposition.

Carcinogenesis - 1 Apr 2013

Kwan Pak Shing, Lau Chi Chiu, Chiu Yung Tuen, Man Cornelia, Liu Ji, Tang Kai Dun, Wong Yong Chuan, Ling Ming-Tat

Abstract excerpt

Mitotic progression of mammalian cells is tightly regulated by the E3 ubiquitin ligase anaphase promoting complex (APC)/C. Deregulation of APC/C is frequently observed in cancer cells and is suggested to contribute to chromosome instability and cancer predisposition. In this study, we identified Daxx as a novel APC/C inhibitor frequently overexpressed in prostate cancer. Daxx interacts with the APC/C coactivators...

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PMID: 23239745
DOI: 10.1093/carcin/bgs391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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