Article
Effect of hypoxia and TP53 mutation status and cytogenetics of normal and malignant mammary epithelium.
Cancer genetics and cytogenetics - 1 Mar 2006
Vidarsson Hilmar, Steinarsdóttir Margrét, Jónasson Jón Gunnlaugur, Júlíusdóttir Hildur, Hauksdóttir Halla, Hilmarsdóttir Hólmfrídur, Halldórsdóttir Kristín, Ogmundsdóttir Helga M
Abstract excerpt
It has been proposed that hypoxia favors the growth of tumor cells over normal cells, particularly tumor cells carrying TP53 mutations. Cytogenetic studies of breast cancer have shown that highly complex karyotypes seen in direct harvest preparations are rarely detected after short-term culture. In this study, 34 paired samples of breast carcinomas and grossly nontumorous tissue from the same breast were cultured...
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