Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD103.

doi:10.1128/iai.58.5.1481-1484.1990

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Article

Diminished immunogenicity of a recombination-deficient derivative of Vibrio cholerae vaccine strain CVD103.

Infection and immunity - 1 May 1990

Ketley J M, Kaper J B, Herrington D A, Losonsky G, Levine M M

Abstract excerpt

To address potential concerns over the release of genetically engineered live bacterial vaccines, we constructed a recombination-deficient derivative of the Vibrio cholerae O1 vaccine strain CVD103 (CVD103RM). Oral immunization of adult volunteers with CVD103RM showed that the recA mutation signi...

Topics

Antibodies, Bacterial
Cholera Vaccines
Cloning, Molecular
Dose-Response Relationship, Immunologic
Humans
Mutation
Rec A Recombinases
Recombination, Genetic
Vaccination
Vibrio cholerae

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