Effect of mutS and recD mutations on Salmonella virulence.

doi:10.1128/IAI.67.11.6168-6172.1999

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Article

Effect of mutS and recD mutations on Salmonella virulence.

Infection and immunity - 1 Nov 1999

Zahrt T C, Buchmeier N, Maloy S

Abstract excerpt

Hybrid derivatives of closely related bacteria may be used to dissect strain-specific functions that contribute to virulence within a host. However, mismatches between DNA sequences are a potent barrier to recombination. Recipients with mutS and recD mutations overcome this barrier, allowing construction of genetic hybrids. To determine whether Salmonella hybrids constructed in a mutS recD host can be used to...

Topics

Adenosine Triphosphatases
Animals
Bacterial Proteins
Base Pair Mismatch
DNA-Binding Proteins
Escherichia coli Proteins
Exodeoxyribonuclease V
Exodeoxyribonucleases
Macrophages, Peritoneal
Mice
MutS DNA Mismatch-Binding Protein
Mutation
Recombination, Genetic
Salmonella
Virulence

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Identifiers

PMID: 10531283
DOI: 10.1128/IAI.67.11.6168-6172.1999
PMCID: PMC97009

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