A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability.

doi:10.1016/s0264-410x(03)00434-1

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Article

A recA deletion mutant of Mycobacterium bovis BCG confers protection equivalent to that of wild-type BCG but shows increased genetic stability.

Vaccine - 1 Oct 2003

Sander Peter, Böttger Erik C, Springer Burkhard, Steinmann Beate, Rezwan Mandana, Stavropoulos Evangelos, Joseph Colston M

Abstract excerpt

The widely used vaccine against tuberculosis, BCG, shows evidence of genetic instability. It has undergone major genetic rearrangements resulting in deletion and duplication of segments of its chromosome. In order to produce a BCG strain with more favourable genetic properties, we inactivated the recA gene. Targeted deletion of the recA gene of BCG resulted in a complete loss of recombination between homologous,...

Topics

Animals
Gene Deletion
Mice
Mutation
Mycobacterium bovis
Mycobacterium tuberculosis
Plasmids
Rec A Recombinases
Recombination, Genetic
Tuberculosis
Vaccination

Source

Open in PubMed

Identifiers

PMID: 14505891
DOI: 10.1016/s0264-410x(03)00434-1

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